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Chem Senses. 2016 Jun;41(5):457-71. doi: 10.1093/chemse/bjw022. Epub 2016 Mar 14.

Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.

Author information

1
Department of Biology, The University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA lemon@ou.edu.
2
Department of Biology, The University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA.

Abstract

Oral temperature is a component and modifier of taste perception. Both trigeminal (V) and taste-sensitive cells, including those in the nucleus of the solitary tract (NTS), can respond to oral temperature. However, functional associations in thermal sensitivity between V and gustatory neurons are poorly understood. To study this we recorded electrophysiological responses to oral stimulation with cool (9, 15, 25, 32, and 34 °C) and warm (40 and 45 °C) temperatures from medullary V (n = 45) and taste-sensitive NTS (n = 27) neurons in anesthetized mice. Results showed temperatures below 34 °C activated the majority of V neurons but only a minority of NTS units. V neurons displayed larger responses to cooling and responded to temperatures that poorly stimulated NTS cells. Multivariate analyses revealed different temperatures induced larger differences in responses across V compared with NTS neurons, indicating V pathways possess greater capacity to signal temperature. Conversely, responses to temperature in NTS units associated with gustatory tuning. Further analyses identified two types of cooling-sensitive V neurons oriented toward innocuous or noxious cooling. Multivariate analyses indicated the combined response of these cells afforded distinction among a broad range of cool temperatures, suggesting multiple types of V neurons work together to represent oral cooling.

KEYWORDS:

multisensory; neural coding; nucleus of the solitary tract; taste; temperature; trigeminal

PMID:
26976122
PMCID:
PMC4910675
DOI:
10.1093/chemse/bjw022
[Indexed for MEDLINE]
Free PMC Article

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