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Wien Klin Wochenschr. 2016 Dec;128(Suppl 8):610-613. doi: 10.1007/s00508-016-0989-6. Epub 2016 Mar 14.

Xanthelasma palpebrarum associated with increased cardio-ankle vascular index in asymptomatic subjects.

Author information

1
Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey. dralirizaakyuz@gmail.com.
2
Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey.
3
Department of Cardiology, Faculty of Medicine, Harran University, Şanlıurfa, Turkey.
4
Department of Cardiology, Osmaniye State Hospital, Osmaniye, Turkey.
5
Department of Cardiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.

Abstract

BACKGROUND:

Xanthelasma palpebrarum (XP) is associated with increased risk of ischemic heart disease and myocardial infarction independent of other well-known cardiovascular risk factors. Cardio-ankle vascular index (CAVI) is a novel index of arterial stiffness and important marker of subclinical atherosclerosis. The purpose of this study was to investigate the association between XP and CAVI in asymptomatic subjects.

METHODS:

Consecutive 50 subjects with XP and age-gender matched 50 control subjects were enrolled. Patients with known atherosclerotic vascular disease were excluded. Arterial stiffness was assessed by CAVI and defined as abnormal if CAVI is ≥ 8.

RESULTS:

Subjects with XP had higher mean CAVI than control subjects (8.05 ± 1.72 vs. 6.76 ± 1.18, p < 0.001). Frequency of abnormal CAVI was higher in subjects with XP (n = 27) compared to those without XP (n = 9, 54 vs. 18 %, p < 0.001). There was a significant correlation between XP and CAVI (r = 0.42, p < 0.001). Conditional logistic regression analysis showed that XP (odds ratio OR 8.80, 95 % confidence interval CI 2.63-29.49, p < 0.001) and age (OR 1.17, 95 % CI 1.08-1.26, p < 0.001) were independent predictors for abnormal CAVI.

CONCLUSION:

The study suggests that XP is associated with increased arterial stiffness in asymptomatic subjects.

KEYWORDS:

Cardio-ankle vascular index; Subclinical atherosclerosis; Xanthelasma

PMID:
26975453
DOI:
10.1007/s00508-016-0989-6
[Indexed for MEDLINE]

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