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J Nat Prod. 2016 Apr 22;79(4):784-91. doi: 10.1021/acs.jnatprod.5b00810. Epub 2016 Mar 14.

Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.

Author information

1
Sarawak Biodiversity Centre , KM20, Jalan Borneo Heights, Semengoh, Locked Bag No. 3032, Kuching 93990, Sarawak Malaysia.
2
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.
3
Department of Plant Sciences, University of Oxford , South Parks Road, Oxford OX1 3RB, United Kingdom.

Abstract

Four new 2,3-secodammarane triterpenoids, stellatonins A-D (3-6), together with a new 3,4-secodammarane triterpenoid, stellatonin E (7), and the known silvestrol (1), 5‴-episilvestrol (2), and β-sitosterol, were isolated from a methanol extract of the stems of Aglaia stellatopilosa through bioassay-guided fractionation. The structures of the new compounds were elucidated using spectroscopic and chemical methods. The compounds were evaluated for their cytotoxic activity against three human cancer cell lines and for their antimicrobial activity using a microtiter plate assay against a panel of Gram-positive and Gram-negative bacteria and fungi.

PMID:
26974604
PMCID:
PMC4841703
DOI:
10.1021/acs.jnatprod.5b00810
[Indexed for MEDLINE]
Free PMC Article

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