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J Adolesc Young Adult Oncol. 2016 Sep;5(3):297-302. doi: 10.1089/jayao.2015.0068. Epub 2016 Mar 14.

Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications.

Author information

1
1 Integrated Cancer Genomics Division, Translational Genomics Research Institute , Phoenix, Arizona.
2
2 Hyundai Cancer Genomics Center, Children's Hospital of Orange County , Orange, California.
3
3 Division of Hematology-Oncology, Department of Medicine, School of Medicine, University of California-Irvine , Orange, California.
4
4 Department of Epidemiology, School of Medicine, University of California-Irvine , Orange, California.
5
5 Department of Pediatrics, School of Medicine, University of California-Irvine , Orange, California.
6
6 Marian University Osteopathic Medical School , Indianapolis, Indiana.
7
7 Department of Radiology, Children's Hospital of Orange County , Orange, California.
8
8 Department of Pathology, Children's Hospital of Orange County , Orange, California.
9
9 Department of Pathology, School of Medicine, University of California-Irvine , Orange, California.
10
10 Neurogenomics Division, Translational Genomics Research Institute , Phoenix, Arizona.

Abstract

Glassy cell carcinoma of the cervix (GCCC) is a very rare and aggressive form of cervical cancer. An adolescent female with advanced metastatic disease was enrolled in our genomic profiling research protocol. We identified high-level amplification of epidermal growth factor receptor (EGFR) and Yes-associated protein-1 (YAP1), which led to the addition of EGFR inhibitors to the chemotherapy regimen. Here, we report the first genetically profiled case of GCCC with potential therapeutic implications.

KEYWORDS:

carcinoma; cervical cancer; chemotherapy; gene regulation; imaging; treatment

PMID:
26974246
DOI:
10.1089/jayao.2015.0068
[Indexed for MEDLINE]

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