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Nat Genet. 2016 May;48(5):497-9. doi: 10.1038/ng.3527. Epub 2016 Mar 14.

Epigenetic germline inheritance of diet-induced obesity and insulin resistance.

Huypens P1,2,3, Sass S4, Wu M1,2, Dyckhoff D1,2,3, Tschöp M3,5,6, Theis F4,7, Marschall S1,2, Hrabě de Angelis M1,2,3,8, Beckers J1,2,3,8.

Author information

1
Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
2
German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
3
German Center for Diabetes Research (DZD), Neuherberg, Germany.
4
Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
5
Institute of Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, Germany.
6
Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany.
7
Department of Mathematics, Technische Universität München, Garching, Germany.
8
Chair of Experimental Genetics, Technische Universität München, Freising, Germany.

Abstract

There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.

PMID:
26974008
DOI:
10.1038/ng.3527
[Indexed for MEDLINE]

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