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Am J Ophthalmol. 2016 May;165:154-63. doi: 10.1016/j.ajo.2016.03.008. Epub 2016 Mar 10.

Spectral-Domain Optical Coherence Tomography-Derived Characteristics of Bruch Membrane Opening in a Young Adult Australian Population.

Author information

1
Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. Electronic address: prseye@gmail.com.
2
Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia.
3
Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.

Abstract

PURPOSE:

To characterize and quantify Bruch membrane opening (BMO)-based optic nerve head (ONH) parameters in a large, young and healthy, predominantly white population.

DESIGN:

Cross-sectional study and reliability analysis.

METHODS:

The ONH of 1344 predominantly white subjects were imaged with spectral-domain optical coherence tomography (SD-OCT). A customized script, coded in Matlab, was used to manually segment and measure multiple BMO-based parameters of the ONH. Measurements were compared to those obtained with confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph; HRT). Regression analysis was performed to assess the relationship between BMO parameters and other ocular and demographic variables.

RESULTS:

Mean BMO disc and neuroretinal rim (NRR) areas ranged from 0.94 to 4.06 mm(2) (mean 1.77 ± 0.38 mm(2)) and 0.94 to 3.99 mm(2) (mean 1.56 ± 0.31 mm(2)), respectively. When compared to the equivalent HRT measurements, SD-OCT-derived measures differed significantly for all comparable ONH parameters (P < .001). The limits of agreement computed from Bland-Altman plots comparing SD-OCT and HRT measurements showed suboptimal agreement between the techniques. Linear regression analysis demonstrated an effect of ethnicity, axial length, and refractive error on BMO-based parameters.

CONCLUSIONS:

We have quantified BMO-based parameters in a large cohort of young adults using SD-OCT. These data will be informative in constructing normative profiles for clinical and research purposes in glaucoma diagnosis and management.

PMID:
26973051
DOI:
10.1016/j.ajo.2016.03.008
[Indexed for MEDLINE]

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