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Nat Rev Immunol. 2016 Apr;16(4):259-71. doi: 10.1038/nri.2016.19. Epub 2016 Mar 14.

Paediatric HIV infection: the potential for cure.

Author information

1
Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
2
The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne 3000, Australia.
3
Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne 3004, Australia.

Abstract

Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.

PMID:
26972723
PMCID:
PMC5694689
DOI:
10.1038/nri.2016.19
[Indexed for MEDLINE]
Free PMC Article

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