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Brain Res. 2016 Jul 1;1642:219-225. doi: 10.1016/j.brainres.2016.03.010. Epub 2016 Mar 10.

Analysis of anti-depressant potential of curcumin against depression induced male albino wistar rats.

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Laboratory of Medicine, Shandong Mental Health Center, Jinan 250014, Shandong, China.
Laboratory of Medicine, Jinan Infectious Disease Hospital, Shandong University, No.22029 Jingshi Road, Jinan 250021, Shandong, China.
Blood Group Reference Laboratory, Shandong Blood Center, Jinan 250014, Shandong, China.
Laboratory of Medicine, Shangdong Provincial Hospital Affiliated to Shandong University, Jinan 250022, Shandong, China.


The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcumin significantly reduced olfactory bulbectomy-induced behavioral abnormalities including deficits in step-down passive avoidance, increased activity in the open area and immobility time. Chronic administration of curcumin significantly reversed levels of 3, 4-dihydroxyphenylacetic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid in the hippocampus region of male albino rats. Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats.


Curcumin; Dopamine; Noradrenaline; Rats; Swim test

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