Format

Send to

Choose Destination
Cancer Med. 2016 Jun;5(6):1352-8. doi: 10.1002/cam4.682. Epub 2016 Mar 13.

History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).

Author information

1
Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
2
Department of Neurological Surgery, University of California, San Francisco, California.
3
Department of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
4
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
5
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut.
6
Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts.
7
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
8
Department of Epidemiology and Biostatistics, Georgia State University School of Public Health, Atlanta, Georgia.
9
Department of Community and Family Medicine, Cancer Control and Prevention Program, Duke University Medical Center, Durham, North Carolina.
10
Department of Surgery, Duke University Medical Center, Durham, North Carolina.
11
Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
12
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
13
Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
14
Department of Neurology, NorthShore University HealthSystem, Evanston, Illinois.
15
Department of Public Health Services, University of Alberta, Edmonton, Alberta, Canada.
16
Departments of Neurology, Neurosurgery, and Preventive Medicine, The University of Southern California Keck School of Medicine, Los Angeles, California.
17
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
18
Department of Community and Family Medicine, Department of Genetics, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
19
Department of Radiation Sciences Oncology, Umeå University, Umeå, Sweden.

Abstract

Varicella zoster virus (VZV) is a neurotropic α-herpesvirus that causes chickenpox and establishes life-long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse association with glioma. The Glioma International Case-Control Study (GICC) is a large, multisite consortium with data on 4533 cases and 4171 controls collected across five countries. Here, we utilized the GICC data to confirm the previously reported associations between history of chickenpox and glioma risk in one of the largest studies to date on this topic. Using two-stage random-effects restricted maximum likelihood modeling, we found that a positive history of chickenpox was associated with a 21% lower glioma risk, adjusting for age and sex (95% confidence intervals (CI): 0.65-0.96). Furthermore, the protective effect of chickenpox was stronger for high-grade gliomas. Our study provides additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental. Future studies, including meta-analyses of the literature and investigations of the potential biological mechanism, are warranted.

KEYWORDS:

Brain tumor; chickenpox; glioma; shingles

PMID:
26972449
PMCID:
PMC4924393
DOI:
10.1002/cam4.682
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center