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J Nat Med. 2016 Jul;70(3):610-9. doi: 10.1007/s11418-016-0984-2. Epub 2016 Mar 14.

Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice.

Author information

1
Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden Mem. Sun Yat-sen, No. 1 Qianhuhoucun, P. O. Box 1435, Nanjing, 210014, China.
2
School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China.
3
Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden Mem. Sun Yat-sen, No. 1 Qianhuhoucun, P. O. Box 1435, Nanjing, 210014, China. njgzhou@163.com.
4
Dongtai Institute of Tidal Flat, Nanjing Branch of Chinese Academy of Sciences, Dongtai, 224200, China. njgzhou@163.com.

Abstract

The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ELC (50, 100, 200 and 400 mg/kg) before ethanol-induced ulcer increased the gastric mucus content, restored the superoxide dismutase and glutathione levels, reduced malondialdehyde levels and inhibited the activity of myeloperoxidase. Furthermore, ELC displayed its anti-secretory activity by decreasing the gastric juice and increased the gastric pH and reduced pro-inflammatory markers and caspase-3 tissue levels. These results suggest that L. chinense displays gastroprotective properties as a result of its antioxidant, anti-inflammatory, anti-secretory and anti-apoptotic effects.

KEYWORDS:

Anti-inflammatory; Antioxidant; Cortex Lycii; Ethanol; Lycium chinense

PMID:
26972100
DOI:
10.1007/s11418-016-0984-2
[Indexed for MEDLINE]

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