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Biochim Biophys Acta. 2016 Aug;1857(8):1086-1101. doi: 10.1016/j.bbabio.2016.03.012. Epub 2016 Mar 10.

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.

Author information

1
Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary. Electronic address: laszlo.tretter@eok.sote.hu.
2
MTA-SE Lendület Hereditary Endocrine Tumours Research Group, Budapest 1088, Hungary.
3
Department of Medical Biochemistry, Semmelweis University, Budapest 1094, Hungary; MTA-SE Lendület Neurobiochemistry Research Group, Budapest 1094, Hungary.

Abstract

Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions.(1).

KEYWORDS:

Cancer; HIF1-alpha; Substrate-level phosphorylation; Succinate dehydrogenase; Succinate receptor

PMID:
26971832
DOI:
10.1016/j.bbabio.2016.03.012
[Indexed for MEDLINE]
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