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Protein Sci. 2016 Jul;25(7):1363-5. doi: 10.1002/pro.2919. Epub 2016 Mar 23.

Presenilin adopts the ClC channel fold.

Author information

1
Department of Biochemistry, Brandeis University, Waltham, Massachusetts, 02453.

Abstract

Presenilin is an integral membrane aspartate protease that regulates cellular processes by cleaving proteins within the cell membrane. The recent crystal structure of presenilin reveals a conspicuous pore in a bundle of nine α-helices, which was originally thought to adopt a novel protein fold. However, here I show that the presenilin fold is a variant of the ClC chloride channel/transporter fold. This observation may have important implications for presenilin's postulated biological role as a calcium leak channel.

KEYWORDS:

ClC channel; calcium leak channel; presenilin; protein fold

PMID:
26971579
PMCID:
PMC4918416
DOI:
10.1002/pro.2919
[Indexed for MEDLINE]
Free PMC Article

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