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Environ Pollut. 2016 May;212:519-524. doi: 10.1016/j.envpol.2016.02.050. Epub 2016 Mar 10.

Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan.

Author information

1
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
2
Department of Epidemiology, College for Public Health and Social Justice, Saint Louis University, Saint Louis 63104, USA.
3
School of Social Work, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO 63104, USA.
4
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
5
Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
6
Department of Epidemiology and Biostatistics, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
7
Institute of Occupational Medicine and Industrial Hygiene and Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan, ROC; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
8
Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn.
9
Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan, ROC. Electronic address: leolee@ntu.edu.tw.

Abstract

To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.

KEYWORDS:

Children; Hyperuricemia; Perfluoroalkyl substances; Uric acid

PMID:
26970855
DOI:
10.1016/j.envpol.2016.02.050
[Indexed for MEDLINE]

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