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Curr Top Dev Biol. 2016;116:45-64. doi: 10.1016/bs.ctdb.2015.11.009. Epub 2016 Feb 1.

Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair.

Author information

1
Developmental Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. Electronic address: cbirch@mdc-berlin.de.
2
The Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address: david.bennett@ndcn.ox.ac.uk.

Abstract

Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.

KEYWORDS:

Myelination; Nrg1; Peripheral nervous system; Remyelination

PMID:
26970613
DOI:
10.1016/bs.ctdb.2015.11.009
[Indexed for MEDLINE]

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