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J Biochem. 2016 Jul;160(1):1-10. doi: 10.1093/jb/mvw022. Epub 2016 Mar 11.

The diet-microbiota-metabolite axis regulates the host physiology.

Author information

1
Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan.
2
Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science the University of Tokyo, Tokyo 108-8639, Japan hase-kj@pha.keio.ac.jp.

Abstract

The intestinal microbiota has been implicated in a wide range of diseases, including inflammatory bowel disease, obesity and cancer. Food ingredients are considered a major determinant of gut microbial composition, as exemplified by high-fat diet-induced dysbiosis that can affect host physiology. Accumulating studies show that microbial metabolites are key regulators of the intestinal epithelial barrier and gut immunity. In particular, short-chain fatty acids produced by bacterial fermentation of indigestible polysaccharides have profound impacts on host physiology beyond the gut. In this review, we describe the influences of the diet-microbiota-metabolite axis on host physiology, and especially on the immune and metabolic systems.

KEYWORDS:

commensal microbiota; diet; epithelial barrier; immune system; short chain fatty acid

PMID:
26970281
DOI:
10.1093/jb/mvw022
[Indexed for MEDLINE]

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