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Wound Repair Regen. 2016 Mar;24(2):204-14. doi: 10.1111/wrr.12415. Epub 2016 Mar 10.

Pericytes: A newly recognized player in wound healing.

Bodnar RJ1,2,3, Satish L2,4, Yates CC1,2,3,5, Wells A1,2,3.

Author information

1
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
2
McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania.
3
Veterans Affairs Medical Center, Pittsburgh, Pennsylvania.
4
Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
5
Department of Health Promotions and Development, University of Pittsburgh, Pittsburgh, Pennsylvania.

Abstract

Pericytes have generally been considered in the context of stabilizing vessels, ensuring the blood barriers, and regulating the flow through capillaries. However, new reports suggest that pericytes may function at critical times to either drive healing with minimal scarring or, perversely, contribute to fibrosis and ongoing scar formation. Beneficially, pericytes probably drive much of the vascular involution that occurs during the transition from the regenerative to the resolution phases of healing. Pathologically, pericytes can assume a fibrotic phenotype and promote scarring. This perspective will discuss pericyte involvement in wound repair and the relationship pericytes form with the parenchymal cells of the skin. We will further evaluate the role pericytes may have in disease progression in relation to chronic wounds and fibrosis.

PMID:
26969517
PMCID:
PMC5036393
DOI:
10.1111/wrr.12415
[Indexed for MEDLINE]
Free PMC Article

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