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Cell Mol Life Sci. 2016 May;73(10):2053-77. doi: 10.1007/s00018-016-2168-3. Epub 2016 Mar 11.

Microtubule plus-end tracking proteins in neuronal development.

Author information

1
Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
2
Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. c.hoogenraad@uu.nl.
3
Cell Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. a.akhmanova@uu.nl.

Abstract

Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

KEYWORDS:

CLASP; CLIP; Cytoskeleton; Development; EB; Microtubule; Neuron; Plus-end tracking proteins; Polarity

PMID:
26969328
PMCID:
PMC4834103
DOI:
10.1007/s00018-016-2168-3
[Indexed for MEDLINE]
Free PMC Article

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