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Cell. 2016 Mar 10;164(6):1288-1300. doi: 10.1016/j.cell.2016.02.037.

Signaling in Host-Associated Microbial Communities.

Author information

1
Department of Bioengineering and Therapeutic Sciences and California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: fischbach@fischbachgroup.org.
2
Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA. Electronic address: jsegre@nhgri.nih.gov.

Abstract

Human-associated microbiota form and stabilize communities based on interspecies interactions. We review how these microbe-microbe and microbe-host interactions are communicated to shape communities over a human's lifespan, including periods of health and disease. Modeling and dissecting signaling in host-associated communities is crucial to understand their function and will open the door to therapies that prevent or correct microbial community dysfunction to promote health and treat disease.

PMID:
26967294
PMCID:
PMC4801507
DOI:
10.1016/j.cell.2016.02.037
[Indexed for MEDLINE]
Free PMC Article

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