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Colloids Surf B Biointerfaces. 2016 Jun 1;142:290-296. doi: 10.1016/j.colsurfb.2016.01.040. Epub 2016 Jan 23.

Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles.

Author information

1
School of Integrative Engineering, Chung-Ang University, Seoul 156-756, Republic of Korea.
2
Department of Bionano Engineering, Hanyang University ERICA, Ansan 426-791, Republic of Korea.
3
School of Integrative Engineering, Chung-Ang University, Seoul 156-756, Republic of Korea; Department of Bionano Engineering, Hanyang University ERICA, Ansan 426-791, Republic of Korea.
4
Russell H. Morgan Department of Radiology and Radiological Health, Johns Hopkins University School of Medicine, Baltimore MD, USA; Cellular Imaging Section, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
5
School of Integrative Engineering, Chung-Ang University, Seoul 156-756, Republic of Korea. Electronic address: jonghoonc@gmail.com.

Abstract

Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5nm and 5nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor α, with a minimal concentration of MPA. In conclusion, IOS/M may have potential applications in both efficient drug delivery and MRI.

KEYWORDS:

Drug delivery; Immunosuppressive drug; Iron oxide nanoparticles; Magnetic resonance imaging; Mycophenolic acid

PMID:
26966999
DOI:
10.1016/j.colsurfb.2016.01.040
[Indexed for MEDLINE]

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