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Biosci Biotechnol Biochem. 2016 Jun;80(6):1192-5. doi: 10.1080/09168451.2016.1146065. Epub 2016 Mar 11.

Orally administered hyaluronan affects skin dryness and epidermal thickening in photoaged hairless mice.

Author information

1
a R&D Division , Kewpie Corporation , Chofu-shi, Tokyo , Japan.
2
b Laboratory of Applied Protein Chemistry, Faculty of Agriculture , Tokyo University of Agriculture and Technology , Fuchu-shi, Tokyo , Japan.

Abstract

The oral administration of hyaluronans (HAs) (molecular weight, 300k and less than 10k) to photoaged hairless mice increased the moisture content of the stratum corneum and decreased the epidermal thickness, respectively. Furthermore, orally administered HAs suppressed the low-molecular weight of HA content of the skin. This study indicates oral administered HAs may ameliorate the skin condition resulting from photoaging.

KEYWORDS:

epidermal thickening; hyaluronan; moisture content of stratum corneum; photoaging; ultraviolet irradiation

PMID:
26966834
DOI:
10.1080/09168451.2016.1146065
[Indexed for MEDLINE]

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