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Cereb Cortex. 2017 Mar 1;27(3):2095-2110. doi: 10.1093/cercor/bhw065.

The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity.

Author information

1
Institute of Neuroscience and Medicine (INM-1, INM-3), Research Centre Jülich, Jülich, Germany.
2
Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
3
Brainnetome Center, Institute of Automation and.
4
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
5
Department of Neurology, Cologne University Hospital, Cologne, Germany.
6
Research Imaging Institute, University of Texas Health Science Center at San Antonio, TX, USA.
7
Centre for Urban Epidemiology (CUE), Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
8
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, China.

Abstract

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our connectivity-based parcellation results with parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into 5 distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found 1) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory, 2) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and 3) a caudal subregion closely integrated with the motor system. Additionally, we found 4) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and 5) a ventral subregion, whose functional profile fits the concept of an eye movement-related field. In conclusion, right PMd may be considered as a functional mosaic formed by 5 subregions.

KEYWORDS:

activation likelihood estimation; clustering; functional connectivity; parcellation; premotor cortex

PMID:
26965906
PMCID:
PMC5963821
DOI:
10.1093/cercor/bhw065
[Indexed for MEDLINE]
Free PMC Article

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