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J Matern Fetal Neonatal Med. 2017 Jan;30(2):134-140. Epub 2016 Apr 6.

The influence of birth weight amongst 33-35 weeks gestational age (wGA) infants on the risk of respiratory syncytial virus (RSV) hospitalisation: a pooled analysis.

Author information

1
a Neonatology Service, Hospital Clinic.Institut d'Investigacios Biomediques August Pi Suñer (IDIBAPS) , Barcelona , Spain.
2
b Strategen Limited , Herriard , Park Estate, Herriard, Basingstoke, UK.
3
c Former Employee of AbbVie , Chicago , IL , USA.
4
d Department of Neonatology , Centre d'Etudes Périnatales de l'Océan Indien and CIC-EC, University Hospital, GHSR , Reunion , France.
5
e Paediatrics and Neonatology Unit, Hospital of Imola , Italy.
6
f Department of Paediatrics , Queen Alexandra Hospital , Portsmouth , UK , and.
7
g Department of Paediatric Infectiology and Immunology , University Children's Hospital, University of Würzburg , Würzburg , Germany.

Abstract

OBJECTIVE:

To investigate the association between birth weight and respiratory syncytial virus (RSV) hospitalisation during the first year of life in 33°-356 weeks' gestational age (wGA) infants.

STUDY DESIGN:

Pooled analysis of data (n = 1218) from Spain, Germany, France and Italy.

RESULT:

RSV hospitalised infants overall had a significantly higher birth weight than non-hospitalised infants (2.24 versus 2.14 kg; p < 0.001) for both males (2.25 versus 2.18 kg; p = 0.049) and females (2.22 versus 2.11 kg, p = 0.007). The effect was significant only in 34 wGA infants (33 wGA: hospitalised 1.95 kg versus non-hospitalised 1.95 kg, p = 0.976; 34 wGA: 2.26 versus 2.14 kg, p = 0.007; 35 wGA: 2.37 versus 2.29 kg, p = 0.070), particularly female 34 wGA infants (female: 2.24 versus 2.08 kg, p = 0.019; male: 2.27 versus 2.20, p = 0.191). Birth weight was shown to be an independent risk factor for RSV hospitalisation.

CONCLUSIONS:

In 33-35 wGA infants, a higher birth weight appeared independently associated with an increased risk of RSV hospitalisation.

KEYWORDS:

Bronchiolitis; lower respiratory tract infection; moderate preterm; prematurity; risk factors

PMID:
26965584
DOI:
10.3109/14767058.2016.1165199
[Indexed for MEDLINE]

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