Format

Send to

Choose Destination
J Asian Nat Prod Res. 2016 Aug;18(8):798-803. doi: 10.1080/10286020.2016.1158710. Epub 2016 Mar 10.

A potent antibacterial indole alkaloid from Psychotria pilifera.

Author information

1
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
2
c University of Chinese Academy of Sciences , Beijing 100049 , China.
3
b Department of Chemistry , COMSATS Institute of Information Technology , Abbottabad 22060 , Pakistan.

Abstract

A new strychnine alkaloid, 16,17,19,20-tetrahydro-2,16-dehydro-18-deoxyisostrychnine (1), and fourteen known alkaloids were isolated from the leaves of Psychotria pilifera. Their structures were identified on the basis of extensive spectroscopic analysis, as well as by comparison with the reported spectroscopic data. The new alkaloid (1) exhibited potent antibacterial activity against Escherichia coli, equivalent to cefotaxime with MIC value of 0.781 μg/ml.

KEYWORDS:

16,17,19,20–tetrahydro–2,16–dehydro–18–deoxyisostrychnine; Psychotria pilifera; Rubiaceae; antibacterial activity; indole alkaloid

PMID:
26963582
DOI:
10.1080/10286020.2016.1158710
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center