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Cell Host Microbe. 2016 Mar 9;19(3):304-10. doi: 10.1016/j.chom.2016.02.013.

Macrophages and HIV-1: An Unhealthy Constellation.

Author information

1
The Sir William Dunn School of Pathology, The University of Oxford, Oxford OX13RE, UK. Electronic address: Quentin.sattentau@path.ox.ac.uk.
2
Department of Medicine, University of Miami Miller School of Medicine, FL 33133, USA,. Electronic address: MStevenson@med.miami.edu.

Abstract

Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.

KEYWORDS:

HIV-1; macrophage; pathogenesis; reservoir

PMID:
26962941
PMCID:
PMC5453177
DOI:
10.1016/j.chom.2016.02.013
[Indexed for MEDLINE]
Free PMC Article

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