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Bonekey Rep. 2016 Mar 2;5:793. doi: 10.1038/bonekey.2016.20. eCollection 2016.

Therapeutic actions of curcumin in bone disorders.

Author information

1
Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney , Sydney, New South Wales, Australia.
2
Advanced Drug Delivery Group, Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia; INSERM, U791, LIOAD, Nantes, France.

Abstract

Curcumin is the active component of turmeric extract derived from the Curcuma longa plant. In the last decade, curcumin has raised a considerable interest in medicine owing to its negligible toxicity and multiple therapeutic actions including anti-cancer, anti-inflammatory and anti-microbial activities. Among the various molecular targets of curcumin, some are involved in bone remodeling, which strongly suggests that curcumin can affect the skeletal system. The review sheds light on the current and potential applications of curcumin to treat bone disorders characterized by an excessive resorption activity. Within the scope of this review, the novel formulations of curcumin to overcome its physico-chemical and pharmacokinetic constraints are also discussed.

PMID:
26962450
PMCID:
PMC4774085
[Available on 2017-03-02]
DOI:
10.1038/bonekey.2016.20

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