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Sci Rep. 2016 Mar 10;6:23067. doi: 10.1038/srep23067.

FNDC5 is produced in the stomach and associated to body composition.

Author information

1
Grupo Fisiopatología Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS). Santiago de Compostela, Spain.
2
Departamento de Pediatría, Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS). Santiago de Compostela, Spain.
3
CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Santiago de Compostela, Spain.
4
Department of Physiology, Research Centre of Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS). Santiago de Compostela, Spain.
5
Unidad de Proteómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago CHUS/SERGAS. Santiago de Compostela, Spain.
6
Departamento de Ciencias Morfológicas, Facultad de Medicina, Universidade de Santiago de Compostela. Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS). Santiago de Compostela, Spain.
7
Grupo Obesidomica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS). Santiago de Compostela, Spain.
8
Laboratorio de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain.

Abstract

The fibronectin type III domain-containing protein 5 (FNDC5) discovered in 2002 has recently gained attention due to its potential role in protecting against obesity. In rat, no data exist regarding FNDC5 production and regulation in the stomach. The aim of the present work was to determine the expression of FNDC5 in the rat stomach and its potential regulation by body composition. The present data shows FNDC5 gene expression in the gastric mucosa. Immunohistochemical studies found FNDC5 immunopositivity in chief cells of gastric tissue. By the use of three different antibodies FNDC5 was found expressed in gastric mucosa and secreted by the stomach. The rate of gastric FNDC5 secretion parallels the circulating levels of FNDC5. The body fat mass increase after intervention with high fat diet coincided with a decrease in the secretion of FNDC5 from the stomach and a diminution in the FNDC5 circulating levels. In summary, the present data shows, for the first time, the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasis.

PMID:
26961074
PMCID:
PMC4785389
DOI:
10.1038/srep23067
[Indexed for MEDLINE]
Free PMC Article

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