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Cell Calcium. 2016 Mar;59(2-3):140-4. doi: 10.1016/j.ceca.2016.02.003. Epub 2016 Feb 28.

Calcium signalling in pancreatic stellate cells: Mechanisms and potential roles.

Author information

1
Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK; Bogomoletz Institute of Physiology, Kiev 01024, Ukraine.
2
Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK.
3
Medical Research Council Group, Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK. Electronic address: PetersenOH@cardiff.ac.uk.

Abstract

Hepatic and pancreatic stellate cells may or may not be regarded as stem cells, but they are capable of remarkable transformations. There is less information about stellate cells in the pancreas than in the liver, where they were discovered much earlier and therefore have been studied longer and more intensively than in the pancreas. Most of the work on pancreatic stellate cells has been carried out in studies on cell cultures, but in this review we focus attention on Ca(2+) signalling in stellate cells in their real pancreatic environment. We review current knowledge on patho-physiologically relevant Ca(2+) signalling events and their underlying mechanisms. We focus on the effects of bradykinin in the initial stages of acute pancreatitis, an often fatal disease in which the pancreas digests itself and its surroundings. Ca(2+) signals, elicited in the stellate cells by the action of bradykinin, may have a negative effect on the outcome of the acute disease process and promote the development of chronic pancreatitis. The bradykinin-elicited Ca(2+) signals can be inhibited by blockade of type 2 receptors and also by blockade of Ca(2+)-release activated Ca(2+) channels. The potential benefits of such pharmacological inhibition for the treatment of pancreatitis are reviewed.

KEYWORDS:

Bradykinin; Bradykinin receptors; Calcium entry; Calcium release; Calcium signalling; Kallikrein; Kininogen

PMID:
26960936
DOI:
10.1016/j.ceca.2016.02.003
[Indexed for MEDLINE]
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