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PLoS One. 2016 Mar 9;11(3):e0150952. doi: 10.1371/journal.pone.0150952. eCollection 2016.

Oral Administration of p-Hydroxycinnamic Acid Attenuates Atopic Dermatitis by Downregulating Th1 and Th2 Cytokine Production and Keratinocyte Activation.

Author information

1
School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
2
Division of Sport Science, College of Natural Sciences, Konkuk University, Chungju, Republic of Korea.
3
College of Pharmacy, Keimyung University, Daegu, Republic of Korea.
4
College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
5
Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Abstract

Atopic dermatitis (AD) is a complex disease that is caused by various factors, including environmental change, genetic defects, and immune imbalance. We previously showed that p-hydroxycinnamic acid (HCA) isolated from the roots of Curcuma longa inhibits T-cell activation without inducing cell death. Here, we demonstrated that oral administration of HCA in a mouse model of ear AD attenuates the following local and systemic AD manifestations: ear thickening, immune-cell infiltration, production of AD-promoting immunoregulatory cytokines in ear tissues, increased spleen and draining lymph node size and weight, increased pro-inflammatory cytokine production by draining lymph nodes, and elevated serum immunoglobulin production. HCA treatment of CD4+ T cells in vitro suppressed their proliferation and differentiation into Th1 or Th2 and their Th1 and Th2 cytokine production. HCA treatment of keratinocytes lowered their production of the pro-inflammatory cytokines that drive either Th1 or Th2 responses in AD. Thus, HCA may be of therapeutic potential for AD as it acts by suppressing keratinocyte activation and downregulating T-cell differentiation and cytokine production.

PMID:
26959360
PMCID:
PMC4784746
DOI:
10.1371/journal.pone.0150952
[Indexed for MEDLINE]
Free PMC Article

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