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J Expo Sci Environ Epidemiol. 2017 Mar;27(2):175-183. doi: 10.1038/jes.2016.8. Epub 2016 Mar 9.

Bisphenol A exposure and children's behavior: A systematic review.

Ejaredar M1,2, Lee Y1, Roberts DJ1,3, Sauve R1,2,4, Dewey D1,2,4.

Author information

1
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
2
Owerko Centre, Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada.
3
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
4
Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Abstract

Bisphenol A (BPA) is an endocrine disrupting chemical used to synthesize polycarbonate plastics and epoxy resins. Previous research suggests that exposure to it can alter children's behavior. The objective of this study is to conduct a systematic review of the existing literature, examining associations between prenatal and childhood BPA exposure and behavior in children up to 12 years of age. We searched electronic bibliographic databases (MEDLINE, PubMed, EMBASE, PsycINFO, CINAHL, and ERIC), reference lists of included articles, and conference abstracts (American Psychiatric Association, American Academy of Neurology, Pediatric Academic Societies, and International Society of Environmental Epidemiology). We included original studies reporting on the association between prenatal and childhood BPA exposure that measured BPA metabolites in urine and children's behavioral outcomes. From 2811 citations, 11 articles met our inclusion criteria. Descriptive analyses indicated that prenatal exposure to maternal BPA concentrations were related to higher levels of anxiety, depression, aggression, and hyperactivity in children. BPA exposure in childhood was associated with higher levels of anxiety, depression, hyperactivity, inattention, and conduct problems. Limited observational evidence suggests an association between both prenatal and childhood exposure to BPA and adverse behavioral outcomes in children. Prospective cohort studies are needed to clarify these associations.

PMID:
26956939
DOI:
10.1038/jes.2016.8
[Indexed for MEDLINE]

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