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Neuropsychologia. 2016 May;85:19-23. doi: 10.1016/j.neuropsychologia.2016.03.002. Epub 2016 Mar 5.

Jumping to conclusions in untreated patients with Parkinson's disease.

Author information

1
Neurology Department/Movement Disorders Sector, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
2
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-4415, United States.
3
Department of Neurology, Cork University Hospital, Cork, Ireland.
4
Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom.
5
Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom; Medical University Innsbruck, Department of Neurology, Innsbruck, Austria. Electronic address: atbin.djamshidian-tehrani@i-med.ac.at.

Abstract

BACKGROUND:

Jumping to conclusions due to impulsivity has been shown to be a sensitive marker for dopamine dysregulation and addictive behaviour patterns in treated patients with Parkinson's disease (PD). It is unknown whether drug naïve PD patients, who have never received dopaminergic therapy also have deficits in information sampling.

METHODS:

Twenty five de novo PD patients and twenty matched healthy controls were recruited and tested on the beads task, which is a validated information sampling task to assess reflection impulsivity and a temporal discounting questionnaire.

RESULTS:

Patients gathered significantly less information and made more irrational choices than matched controls. There was, however, no group difference on the temporal discounting questionnaire.

CONCLUSIONS:

Poor information sampling and irrational decision making may be an inherent component of the neuropsychological deficit in Parkinson's disease. These findings suggest that underlying impulsivity detected by a metric task is common in de novo PD.

[Indexed for MEDLINE]
Free PMC Article

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