The CAR that drives Ca2+ to Orai1

Sci Signal. 2016 Mar 8;9(418):fs5. doi: 10.1126/scisignal.aaf1941.

Abstract

How Ca(2+) permeates the Orai1 channel and the mechanism by which the channel achieves high Ca(2+) selectivity remain critical questions in understanding store-operated Ca(2+) influx. In research published in Science Signaling, Frischauf et al. identified a Ca(2+)-accumulating region (CAR) in the extracellular opening of Orai1, which explains how concentrating Ca(2+) at the mouth of Orai1 facilitates channel permeation and contributes to selectivity.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / chemistry*
  • Calcium / metabolism*
  • Calcium Signaling / physiology*
  • Humans
  • ORAI1 Protein / chemistry*
  • ORAI1 Protein / genetics
  • ORAI1 Protein / metabolism*
  • Protein Domains

Substances

  • ORAI1 Protein
  • ORAI1 protein, human
  • Calcium