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Pediatr Obes. 2017 Apr;12(2):171-178. doi: 10.1111/ijpo.12125. Epub 2016 Mar 8.

Maternal obesity, gestational diabetes, breastfeeding and childhood overweight at age 2 years.

Author information

1
Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
2
Consulting & Implementation, Kaiser Permanente Southern California, Pasadena, CA, USA.
3
Quality and Risk, Kaiser Permanente Southern California, Pasadena, CA, USA.
4
Department of Medicine and Diabetes and Obesity Research Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.

Abstract

BACKGROUND:

Maternal obesity, excessive gestational weight gain (EGWG), gestational diabetes mellitus (GDM) and breastfeeding are four important factors associated with childhood obesity.

OBJECTIVES:

The objective of the study was to assess the interplay among these four factors and their independent contributions to childhood overweight in a cohort with standard clinical care.

METHODS:

The cohort included 15 710 mother-offspring pairs delivered in 2011. Logistic regression was used to assess associations between maternal exposures and childhood overweight (body mass index >85th percentile) at age 2 years.

RESULTS:

Mothers with pre-pregnancy obesity or overweight were more likely to have EGWG, GDM and less likely to breastfeed ≥6 months. Mothers with GDM had 40-49% lower EGWG rates and similar breastfeeding rates compared with mothers without GDM. Analysis adjusted for exposures and covariates revealed an adjusted odds ratio (95% confidence interval) associated with childhood overweight at age 2 years of 2.34 (2.09-2.62), 1.50 (1.34-1.68), 1.23 (1.12-1.35), 0.95 (0.83-1.10) and 0.76 (0.69-0.83) for maternal obesity, overweight, EGWG, GDM and breastfeeding ≥6 months vs. <6 months, respectively.

CONCLUSIONS:

In this large clinical cohort, GDM was not associated with, but maternal pre-pregnancy obesity or overweight and EGWG were independently associated with an increased risk, and breastfeeding ≥6 months was associated with a decreased risk of childhood overweight at age 2 years.

KEYWORDS:

Breastfeeding; gestational diabetes; gestational weight gain; maternal and childhood obesity

PMID:
26956226
DOI:
10.1111/ijpo.12125
[Indexed for MEDLINE]

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