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Neurotoxicology. 2016 May;54:81-88. doi: 10.1016/j.neuro.2016.03.002. Epub 2016 Mar 5.

Childhood exposure to polybrominated diphenyl ethers and neurodevelopment at six years of age.

Author information

1
U1085 Irset Research Institute of Health Environment and Work, Inserm, Rennes, France; University of Rennes 1, Rennes, France. Electronic address: cecile.chevrier@univ-rennes1.fr.
2
U1085 Irset Research Institute of Health Environment and Work, Inserm, Rennes, France; University of Rennes 1, Rennes, France.
3
Research Centre for Psychology, Cognition and Communication, University of Rennes 2, Rennes, France.
4
U1085 Irset Research Institute of Health Environment and Work, Inserm, Rennes, France; Réseau « Bien Naître en Ille et Vilaine », Rennes, France.
5
Laboratoire du Centre de Toxicologie (CTQ), Institut national de santé publique du Québec (INSPQ), Québec, Canada.
6
U1085 Irset Research Institute of Health Environment and Work, Inserm, Rennes, France; EHESP School of Public Health, Sorbonne, Paris Cité, Rennes, France.
7
École de psychologie, Université Laval, Centre de recherche du Centre Hospitalier Universitaire de Québec, Québec, Canada.

Abstract

Mixtures of polybrominated diphenyl ethers (PBDEs) are present in indoor environments. Studies of the developmental effects of exposure to these chemicals in large prospective mother-child cohorts are required, with data on prenatal exposure and long-term follow-up of the children. We aimed to investigate the relationship between prenatal and childhood exposure to PBDEs and neurodevelopment at the age of six years. We determined the levels of PBDEs and other neurotoxicants in cord blood and dust collected from the homes of children for 246 families included in the PELAGIE mother-child cohort in France. We assessed two cognitive domains of the six-year-old children using the Wechsler Intelligence Scale for Children-IV. Verbal comprehension scores were lower in children from homes with higher concentrations of BDE99 (βDetects<median_vs_NonDetects=-1.6; 95% CI: -6.1, 2.9; βDetects≥median_vs_NonDetects=-5.4; -9.9, -1.0; p trend=0.02) and of BDE209 (β2nd_vs_1st_tertile=-1.8; 95% CI: -6.1, 2.5; β3rd_vs_1st_tertile=-3.2; -7.5, 1.2; p trend=0.15) in dust, particularly for boys (p trend=0.02 and 0.04, respectively). Working memory scores seemed to be lower in children with higher BDE99 concentrations in dust (p trend=0.10). No association was observed with cord blood levels of BDE209. Our findings are in agreement with those of four previous studies suggesting adverse cognitive outcomes among children associated with early-life exposure to penta-BDE mixtures, and provide new evidence for the potential neurotoxicity of BDE209. Several countries are in the process of banning the use of PBDE mixtures as flame-retardants. However, these compounds are likely to remain present in the environment for a long time to come.

KEYWORDS:

Brominated flame retardant; Childhood; Exposure; Neurodevelopment; Pregnancy

PMID:
26955917
DOI:
10.1016/j.neuro.2016.03.002
[Indexed for MEDLINE]
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