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Drug Des Devel Ther. 2016 Feb 22;10:767-79. doi: 10.2147/DDDT.S90457. eCollection 2016.

Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells.

Author information

1
Department of Neurosurgery, Huzhou Central Hospital, Huzhou, Zhejiang, People's Republic of China.
2
Nanchang University Medical College, Nanchang, Jiangxi, People's Republic of China.
3
Department of Gastroenterology, The 98th Hospital of Nanjing Military Command, Huzhou, Zhejiang, People's Republic of China.
4
Spleen & Stomach Institute, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
5
Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, People's Republic of China.
6
Bayi Brain Hospital, The Military General Hospital of Beijing PLA, Beijing, People's Republic of China.

Abstract

In this study, we investigated the potential anticancer effects of calycosin against human glioblastoma cells, including the impacts on cell proliferation, apoptosis, and cell cycle distribution. We further studied its inhibitory activity on migration and invasion in U87 and U251 cells. Furthermore, transforming growth factor beta-mediated reductions of mesenchymal-associated genes/activators, matrix metalloproteinases-2, and -9 were detected in this process. Administration of calycosin in a glioblastoma xenograft model showed that calycosin could not only reduce tumor volume but also suppress transforming growth factor beta as well as its downstream molecules. These results revealed calycosin as a potential antitumor agent in human glioblastoma.

KEYWORDS:

calycosin; epithelial–mesenchymal transition (EMT); glioblastoma; invasion; matrix metalloproteinases (MMPs); migration

PMID:
26955262
PMCID:
PMC4769008
DOI:
10.2147/DDDT.S90457
[Indexed for MEDLINE]
Free PMC Article

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