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ACS Nano. 2016 Apr 26;10(4):4199-208. doi: 10.1021/acsnano.5b07483. Epub 2016 Mar 14.

Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery.

Author information

1
Center for Self-assembly and Complexity, Institute for Basic Science (IBS) , Pohang 37673, Republic of Korea.
2
Department of Chemistry, Pohang University of Science and Technology (POSTECH) , Pohang 37673, Republic of Korea.
3
Department of Biomedical Sciences, Seoul National University Graduate School , Seoul 03080, Republic of Korea.

Abstract

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.

KEYWORDS:

calcium phosphate; corneal wound healing; gatekeeper; nitric oxide delivery; pH-jump reagent

PMID:
26953516
DOI:
10.1021/acsnano.5b07483

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