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Mater Sci Eng C Mater Biol Appl. 2016 May;62:605-13. doi: 10.1016/j.msec.2016.02.004. Epub 2016 Feb 6.

β-Cyclodextrin anchoring onto pericarpium granati-derived magnetic mesoporous carbon for selective capture of lopid in human serum and pharmaceutical wastewater samples.

Author information

1
School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China; School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.
2
School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.
3
School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China.
4
School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address: fuqiang@mail.xjtu.edu.cn.

Abstract

Functionalized magnetic carbonaceous nanomaterials, which are important materials with many practical and research applications in biomedical, pharmaceutical and biological fields, have recently attracted much attention. In this study, a magnetic mesoporous carbon coated with β-cyclodextrin (MMC@β-CD) was synthesized for the first time from natural pericarpium granati (PG). The as-obtained MMC@β-CD has high surface areas (203 m(2)g(-1)), large pore volumes (0.16 cm(3)g(-1)), relatively broad mesoporous sizes (6.8 nm) and a high saturation magnetization of 26.2 emu g(-1), which is sufficient for magnetic separation by an external magnetic field. The MMC@β-CD was used as an innovative adsorbent for magnetic solid-phase extraction of lopid via host-guest interaction prior to spectrofluorometric analysis. The proposed method was successfully applied to analyze lopid in human serum and pharmaceutical wastewater samples with recoveries in the range of 85.0-103.5% for the spiked samples. Overall, this work not only provides an inexpensive and eco-friendly method to fabricate MMC@β-CD (or MMC) from PG, but also develops a highly selective approach for capture of lopid in biological samples and environmental substances.

KEYWORDS:

Beta-cyclodextrin; Human serum; Lopid; Magnetic mesoporous carbon; Pericarpium granati; Pharmaceutical wastewaters

PMID:
26952464
DOI:
10.1016/j.msec.2016.02.004
[Indexed for MEDLINE]

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