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J Card Fail. 2016 Jun;22(6):409-16. doi: 10.1016/j.cardfail.2016.02.011. Epub 2016 Mar 4.

Dichotomous Relationship Between Age and 30-Day Death or Rehospitalization in Heart Failure Patients Admitted With Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial.

Author information

1
Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA. Electronic address: david.whellan@jefferson.edu.
2
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA.
3
Canadian VIGOUR Centre at the University of Alberta, Mazankowski Alberta Heart Institute, Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, Alberta, Canada.
4
Western Infirmary and the British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom.
5
Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, Pennsylvania, USA.

Abstract

BACKGROUND:

Younger age as an independent predictor of death or all-cause rehospitalization at 30 days post-randomization for hospitalized heart failure (HF) patients has not been well described.

METHODS AND RESULTS:

ASCEND-HF enrolled 7141 hospitalized acute HF patients (categorized by age: <45, 45 to <55, 55 to <65, 65 to <75, and ≥75 years) and followed them for 30 days to assess clinical outcomes, which included death or rehospitalization. Patients 45 to <55 years had the lowest percentages of death (1.4%) and total rehospitalizations (10.7%); percentages increased for younger (3.0% and 12.2%, respectively, for age <45 y) and older (5.8% and 12.5%, respectively, for age ≥75 y) patients. For those rehospitalized, the total HF-induced readmissions were highest in the youngest (68%) and declined with increasing age (P = .03). Although patients ≥55 years of age were more likely to die or be rehospitalized within 30 days of randomization for each additional 10 years of life, those <55 years of age had a significant reduction in death or HF rehospitalization for each 10-year increase in age (similar findings for death and HF rehospitalization).

CONCLUSIONS:

There is a dichotomous relationship between age and risk of death or rehospitalization, and death or HF rehospitalization-risk decreases as age increases up to age 55 years, then increases after age 55 years.

KEYWORDS:

Heart failure; age; outcomes; rehospitalization

PMID:
26952241
DOI:
10.1016/j.cardfail.2016.02.011
[Indexed for MEDLINE]

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