Format

Send to

Choose Destination
Wiley Interdiscip Rev Dev Biol. 2016 May-Jun;5(3):377-88. doi: 10.1002/wdev.228. Epub 2016 Mar 7.

β-catenin-driven binary cell fate decisions in animal development.

Author information

1
Aix-Marseille Université, CNRS, Institut de Biologie du Développement de Marseille, Marseille, France.

Abstract

The Wnt/β-catenin pathway plays key roles during animal development. In several species, β-catenin is used in a reiterative manner to regulate cell fate diversification between daughter cells following division. This binary cell fate specification mechanism has been observed in animals that belong to very diverse phyla: the nematode Caenorhabditis elegans, the annelid Platynereis, and the ascidian Ciona. It may also play a role in the regulation of several stem cell lineages in vertebrates. While the molecular mechanism behind this binary cell fate switch is not fully understood, it appears that both secreted Wnt ligands and asymmetric cortical factors contribute to the generation of the difference in nuclear β-catenin levels between daughter cells. β-Catenin then cooperates with lineage specific transcription factors to induce the expression of novel sets of transcription factors at each round of divisions, thereby diversifying cell fate. For further resources related to this article, please visit the WIREs website.

PMID:
26952169
PMCID:
PMC5069452
DOI:
10.1002/wdev.228
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center