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Curr Treat Options Oncol. 2016 Apr;17(4):17. doi: 10.1007/s11864-016-0393-5.

Obesity and Metabolic Syndrome Among Adult Survivors of Childhood Leukemia.

Author information

1
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN, 38105, USA. todd.gibson@stjude.org.
2
Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN, 38105, USA. matt.ehrhardt@stjude.org.
3
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 735, Memphis, TN, 38105, USA. kiri.ness@stjude.org.

Abstract

Treatment-related obesity and the metabolic syndrome in adult survivors of childhood acute lymphoblastic leukemia (ALL) are risk factors for cardiovascular disease. Both conditions often begin during therapy. Preventive measures, including dietary counseling and tailored exercise, should be initiated early in the course of survivorship, with referral to specialists to optimize success. However, among adults who develop obesity or the metabolic syndrome and who do not respond to lifestyle therapy, medical intervention may be indicated to manage underlying pathology, such as growth hormone deficiency, or to mitigate risk factors of cardiovascular disease. Because no specific clinical trials have been done in this population to treat metabolic syndrome or its components, clinicians who follow adult survivors of childhood ALL should use the existing American Heart Association/National Heart Lung and Blood Institute Scientific Statement to guide their approach.

KEYWORDS:

Acute lymphoblastic leukemia; Childhood; Cranial radiation; Glucocorticoids; Growth hormone deficiency; Lifestyle; Metabolic syndrome; Obesity; Pediatrics; Survivor

PMID:
26951206
PMCID:
PMC4813812
DOI:
10.1007/s11864-016-0393-5
[Indexed for MEDLINE]
Free PMC Article

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