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Avian Dis. 1989 Oct-Dec;33(4):636-42.

Protection of chicks against Salmonella infection with a mixture of pure cultures of intestinal bacteria.

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Bureau of Microbial Hazards, Health Protection Branch, Ottawa, Ontario, Canada.


A mixture of 28 pure cultures was prepared from the organisms isolated from native gut microflora (fecal and cecal contents) of adult Salmonella-free birds. This mixture was orally administered to 1-day-old chicks and examined for its efficacy against challenge with 10(5) colony-forming units of nalidixic-acid-resistant Salmonella typhimurium in six consecutive trials during a 20-month period. The efficacy of the mixture, which was prepared for each trial from stored isolates, progressively decreased, while that from stored fecal content remained unimpaired. Twenty-three cultures in the mixture were tentatively identified as belonging to seven different genera; the genus of the five other cultures remained unknown.

[Indexed for MEDLINE]

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