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Nanomedicine. 2016 Jul;12(5):1253-62. doi: 10.1016/j.nano.2016.01.005. Epub 2016 Mar 3.

Iron oxide nanoparticles as magnetic relaxation switching (MRSw) sensors: Current applications in nanomedicine.

Author information

1
BIONAND, Andalusian Center for Nanomedicine and Biotechnology, Campanillas, Malaga, Spain.
2
CABIMER, Andalusian Center for molecular Biology and Regenerative Medicine, Isla de la Cartuja, Seville, Spain; Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain.
3
CABIMER, Andalusian Center for molecular Biology and Regenerative Medicine, Isla de la Cartuja, Seville, Spain; Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain. Electronic address: david.pozo@cabimer.es.

Abstract

Since pioneering work in the early 60s on the development of enzyme electrodes the field of sensors has evolved to different sophisticated technological platforms. Still, for biomedical applications, there are key requirements to meet in order to get fast, low-cost, real-time data acquisition, multiplexed and automatic biosensors. Nano-based sensors are one of the most promising healthcare applications of nanotechnology, and prone to be one of the first to become a reality. From all nanosensors strategies developed, Magnetic Relaxation Switches (MRSw) assays combine several features which are attractive for nanomedical applications such as safe biocompatibility of magnetic nanoparticles, increased sensitivity/specificity measurements, possibility to detect analytes in opaque samples (unresponsive to light-based interferences) and the use of homogeneous setting assay. This review aims at presenting the ongoing progress of MRSw technology and its most important applications in clinical medicine.

KEYWORDS:

Biosensors; Magnetic nanoparticles; Magnetic resonance; Nanodiagnostics; Nanoengineering; Nanomedical devices

PMID:
26949164
DOI:
10.1016/j.nano.2016.01.005
[Indexed for MEDLINE]

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