Format

Send to

Choose Destination
Ultrasound Med Biol. 2016 May;42(5):1182-92. doi: 10.1016/j.ultrasmedbio.2016.01.007. Epub 2016 Mar 2.

Improved Estimation of Ultrasound Thermal Strain Using Pulse Inversion Harmonic Imaging.

Author information

1
Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, Pennsylvania, USA; Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, Pennsylvania, USA; Department of Medicine and Heart and Vascular Institute, Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
2
Department of Medicine and Heart and Vascular Institute, Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
3
Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
4
Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, Pennsylvania, USA; Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
5
Department of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
6
Department of Bioengineering, University of Pittsburgh School of Engineering, Pittsburgh, Pennsylvania, USA; Department of Medicine and Heart and Vascular Institute, Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address: kangkim@upmc.edu.

Abstract

Thermal (temporal) strain imaging (TSI) is being developed to detect the lipid-rich core of atherosclerotic plaques and presence of fatty liver disease. However, the effects of ultrasonic clutter on TSI have not been considered. In this study, we evaluated whether pulse inversion harmonic imaging (PIHI) could be used to improve estimates of thermal (temporal) strain. Using mixed castor oil-gelatin phantoms of different concentrations and artificially introduced clutter, we found that PIHI improved the signal-to-noise ratio of TSI by an average of 213% or 52.1% relative to 3.3- and 6.6-MHz imaging, respectively. In a phantom constructed using human liposuction fat in the presence of clutter, the contrast-to-noise ratio was degraded by 35.1% for PIHI compared with 62.4% and 43.7% for 3.3- and 6.6-MHz imaging, respectively. These findings were further validated using an ex vivo carotid endarterectomy sample. PIHI can be used to improve estimates of thermal (temporal) strain in the presence of clutter.

KEYWORDS:

Non-invasive ultrasound thermometry; Oil–gelatin phantom; Pulse inversion harmonic imaging; Temporal strain imaging; Thermal strain imaging; Ultrasound clutter

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center