Format

Send to

Choose Destination
MAGMA. 2016 Jun;29(3):559-70. doi: 10.1007/s10334-016-0531-x. Epub 2016 Mar 5.

High resolution imaging of the intracranial vessel wall at 3 and 7 T using 3D fast spin echo MRI.

Author information

1
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94121, USA. Chengcheng.Zhu@ucsf.edu.
2
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94121, USA.
3
Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
4
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
5
Siemens Healthcare, San Francisco, CA, USA.
6
Radiology Service, VA Medical Center, San Francisco, CA, USA.

Abstract

OBJECTIVES:

High resolution MRI of the intracranial vessel wall provides important insights in the assessment of intracranial vascular disease. This study aims to refine high resolution 3D MRI techniques for intracranial vessel wall imaging at both 3 and 7 T using customized flip angle train design, and to explore their comparative abilities.

MATERIALS AND METHODS:

11 patients with intracranial artery disease (four atherosclerotic plaques, six aneurysms and one reversible cerebral vasoconstriction syndrome) were imaged at 3 and 7 T with a 3D T 1-weighted fast-spin-echo sequence (SPACE) both pre and post Gd contrast injection. Wall to lumen contrast ratio (CRwall-lumen), contrast enhancement ratio (ER) and the sharpness of the vessel wall were quantified. Two experienced radiologists evaluated the image quality on a 0-5 scale.

RESULTS:

Both 3 and 7 T achieved good image quality with high resolution (nominal 0.5 mm isotropic) and whole brain coverage. The CRwall-lumen and the ER measurements were comparable (p > 0.05). The 7 T images were significantly sharper (sharpness: 2.69 ± 0.50 vs. 1.88 ± 0.53 mm(-1), p < 0.001) with higher image quality (reader 1 score: 3.5 ± 1.1 vs. 2.4 ± 1.1, p = 0.002) compared to 3 T.

CONCLUSIONS:

3D T 1-weighted SPACE can be used for intracranial vessel wall evaluation at both 3 and 7 T. 7 T provides significantly better image quality and improves the confidence of diagnosis.

KEYWORDS:

Aneurysm; Atherosclerosis; Contrast enhancement; High resolution MRI; Intracranial vessel wall

PMID:
26946509
DOI:
10.1007/s10334-016-0531-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center