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Virology. 2016 May;492:140-4. doi: 10.1016/j.virol.2016.02.022. Epub 2016 Mar 21.

Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency.

Author information

1
Department of Microbiology and Molecular Genetics, United States.
2
Department of Microbiology and Molecular Genetics, United States; Cancer Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States. Electronic address: vera@mcw.edu.

Abstract

Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.

KEYWORDS:

B-1 B cells; Chronic infection; Gammaherpesvirus

PMID:
26945150
PMCID:
PMC4826794
DOI:
10.1016/j.virol.2016.02.022
[Indexed for MEDLINE]
Free PMC Article

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