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Trends Cell Biol. 2016 Jun;26(6):391-398. doi: 10.1016/j.tcb.2016.02.001. Epub 2016 Mar 2.

Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling.

Author information

1
Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland.
2
Turku Centre for Biotechnology, University of Turku, FIN-20520 Turku, Finland; Department of Biochemistry and Food Chemistry, University of Turku, FIN-20520 Turku, Finland. Electronic address: johanna.ivaska@utu.fi.

Abstract

Integrins are vital cell adhesion receptors with the ability to transmit extracellular matrix (ECM) cues to intracellular signalling pathways. ECM-integrin signalling regulates various cellular functions such as cell survival and movement. Integrin signalling has been considered to occur exclusively from adhesion sites at the plasma membrane (PM). However, recent data demonstrates integrin signalling also from endosomes. Integrin-mediated focal adhesion kinase (FAK) signalling is strongly dependent on integrin endocytosis, and endosomal FAK signalling facilitates cancer metastasis by supporting anchorage-independent growth and anoikis resistance. Here we discuss the possible mechanisms and functions of endosomal FAK signalling compared with its previously known roles in other cellular locations and discuss the potential of endosomal FAK as novel target for future cancer therapies.

KEYWORDS:

Rab21; anoikis; endocytosis; focal adhesion kinase (FAK); integrin signalling; integrin traffic

PMID:
26944773
DOI:
10.1016/j.tcb.2016.02.001
[Indexed for MEDLINE]

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