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Acta Neurol Belg. 2016 Dec;116(4):513-518. Epub 2016 Mar 4.

Factors affecting the quality of life in drug-resistant epilepsy patients.

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Department of Neurology, Trakya University Medical Faculty, 22030, Edirne, Turkey.
Department of Biostatistics, Trakya University Medical Faculty, Edirne, Turkey.
Department of Neurology, Trakya University Medical Faculty, 22030, Edirne, Turkey.


Epilepsy patients whose seizures cannot be controlled by treatment have a lower quality of life (QoL). The aim of the present study was to compare the potential factors affecting the QoL in patients who were seizure-free with medication or who had drug-resistant epilepsy. The study included 46 drug-resistant and 42 seizure-free epilepsy patients. The demographic and clinical features of the patients were investigated for their effects on patient QoL. The QoL was assessed by the QoL in Epilepsy Inventory-89 and depression was detected by the Beck Depression Inventory. The QoL was significantly lower in the drug-resistant patients than in the seizure-free epilepsy patients (p < 0.001). Depression, lower education level, and unemployment were associated with lower QoL scores (p < 0.001, p < 0.01, p < 0.001, respectively). After adjusting for lower education level and unemployment, depression remained as an independent factor affecting QoL (p < 0.05). In addition to their efforts to control and stop seizures, clinicians should remain aware of depression and treat it effectively to improve the QoL of drug-resistant epilepsy patients.


Depression; Drug resistance; Epilepsy; Quality of life

[Indexed for MEDLINE]

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