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Cell Stem Cell. 2016 Mar 3;18(3):295-7. doi: 10.1016/j.stem.2016.02.009.

Sweet Relief: Reprogramming Gastric Endocrine Cells to Make Insulin.

Author information

1
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
2
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address: james.wells@cchmc.org.

Abstract

Two promising approaches toward a cell-based cure for diabetes are the directed differentiation of pluripotent stem cells or lineage reprogramming of other cell types to generate beta cells. In this issue of Cell Stem Cell, Ariyachet et al. (2016) reprogrammed gastric endocrine cells to generate a renewable source of insulin-producing cells.

PMID:
26942844
DOI:
10.1016/j.stem.2016.02.009
[Indexed for MEDLINE]
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