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Mol Cell. 2016 Mar 3;61(5):683-694. doi: 10.1016/j.molcel.2016.02.022.

Mitofusins, from Mitochondria to Metabolism.

Author information

1
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padova, Italy.
2
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padova, Italy; Department of Biology, University of Padua, Via G. Colombo 3, 35121 Padova, Italy. Electronic address: luca.scorrano@unipd.it.

Abstract

Mitochondrial architecture is involved in several functions crucial for cell viability, proliferation, senescence, and signaling. In particular, mitochondrial dynamics, through the balance between fusion and fission events, represents a central mechanism for bioenergetic adaptation to metabolic needs of the cell. As key regulators of mitochondrial dynamics, the fusogenic mitofusins have recently been linked to mitochondrial biogenesis and respiratory functions, impacting on cell fate and organism homeostasis. Here we review the implication of mitofusins in the regulation of mitochondrial metabolism, and their consequence on energy homeostasis at the cellular and physiological level, highlighting their crucial role in metabolic disorders, cancer, and aging.

KEYWORDS:

bioenergetic; mitochondrial dynamics; mitofusins

PMID:
26942673
DOI:
10.1016/j.molcel.2016.02.022
[Indexed for MEDLINE]
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