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Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.

Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Author information

1
Gladstone Institute of Neurological Disease, University of California, San FranciscoSan Francisco, CA, USA; Department of Neurology, University of California, San FranciscoSan Francisco, CA, USA.
2
Departments of Neurology, Pathology and Cell Biology and Pharmacology, Columbia University Medical Center New York, NY, USA.
3
Departments of Chemistry and Molecular and Cell Biology, Howard Hughes Medical Institute, Helen Wills Neuroscience Institute, University of California, Berkeley Berkeley, CA, USA.
4
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation Cleveland, OH, USA.
5
Department of Neurology, Yale University New Haven, CT, USA.
6
Laboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Kavli Institute for Brain Science, Columbia University New York, NY, USA.
7
Departments of Neurobiology and Physiology, David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
8
Department of Physics and Section of Neurobiology, University of California, San Diego La Jolla, CA, USA.
9
Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health Bethesda, MD, USA.
10
Department of Radiology and Biomedical Imaging, University of California, San Francisco San Francisco, CA, USA.
11
Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California Los Angeles, CA, USA.

Abstract

Breakthrough advances in intravital imaging have launched a new era for the study of dynamic interactions at the neurovascular interface in health and disease. The first Neurovascular and Immuno-Imaging Symposium was held at the Gladstone Institutes, University of California, San Francisco in March, 2015. This highly interactive symposium brought together a group of leading researchers who discussed how recent studies have unraveled fundamental biological mechanisms in diverse scientific fields such as neuroscience, immunology, and vascular biology, both under physiological and pathological conditions. These Proceedings highlight how advances in imaging technologies and their applications revolutionized our understanding of the communication between brain, immune, and vascular systems and identified novel targets for therapeutic intervention in neurological diseases.

KEYWORDS:

Alzheimer's disease; blood-brain barrier; microglia; multiple sclerosis; myelin; neuroinflammation; traumatic brain injury; two-photon microscopy

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