Format

Send to

Choose Destination
See comment in PubMed Commons below
Diabetologia. 2016 May;59(5):879-94. doi: 10.1007/s00125-016-3904-9. Epub 2016 Mar 3.

Adipose tissue macrophages: going off track during obesity.

Author information

1
Department of Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.
2
Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, the Netherlands.
3
Department of Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. rinke.stienstra@wur.nl.
4
Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, the Netherlands. rinke.stienstra@wur.nl.

Abstract

Inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals. Although a plethora of different immune cells shapes adipose tissue inflammation, this review is specifically focused on the contribution of macrophages that reside in adipose tissue in lean and obese conditions. Both conventional and tissue-specific functions of adipose tissue macrophages (ATMs) in lean and obese adipose tissue are discussed and linked with metabolic and inflammatory changes that occur during the development of obesity. Furthermore, we will address various circulating and adipose tissue-derived triggers that may be involved in shaping the ATM phenotype and underlie ATM function in lean and obese conditions. Finally, we will highlight how these changes affect adipose tissue inflammation and may be targeted for therapeutic interventions to improve insulin sensitivity in obese individuals.

KEYWORDS:

Adipose tissue; Fat; Immune cells; Inflammation; Insulin resistance; Macrophages; Metabolism; Obesity; Review

PMID:
26940592
PMCID:
PMC4826424
DOI:
10.1007/s00125-016-3904-9
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center